The success of robotic behaviors can only be truly evaluated through implementation in the real world, particularly through translation to clinical settings. Our research evaluates robotic-assisted locomotion in real-world scenarios using computational musculoskeletal models, biomechanical assessment, and clinical evaluation. This interdisciplinary approach sits at the intersection of robotics, biomechanics, clinical rehabilitation science, and human physiology to develop assistive technologies that not only work in theory but truly improve patients’ functional abilities and quality of life.